Narcolepsy-cataplexy in a female dog

阅读量:

52

摘要:

Narcolepsy in human beings is a life-long illness afflicting 100,000–150,000 Americans. No current treatment for this neurological disorder is satisfactory and a definitive approach to the disease requires an animal model of narcolepsy. This report summarizes data on a female toy poodle which has a canine form of narcolepsy-cataplexy. At approximately 4 mo of age, the dog presented cataplectic attacks. Physical examination disclosed no systemic factors to account for such atonic episodes. Observation indicated that attacks were frequently partial, involving only the neck musculature and hind legs. However, such attacks could develop into complete cataplexy, causing postural collapse and areflexia, although extrinsic eye muscles and the muscles of respiration were spared. Presentation of food, water, or a plaything were the most frequent elicitors of attacks. During 41 hr of EEG, EOG, and EMG monitoring in conjunction with behavioral observation, the dog exhibited normal polygraphic wakefulness, slow-wave sleep and REM sleep. Unambiguous sleep onset REM periods and cataplectic attacks were also observed. These pathological manifestations are analogous to those characteristic of human narcolepsy. The diagnosis of canine narcolepsy was further confirmed by two negative trials with neostigmine (ruling out myasthenia) and two positive trials with imipramine (cataplexy in human narcolepsy responds to imipramine treatment). The dog will be bred either with a littermate or a similarly afflicted male in an attempt to produce a population of afflicted dogs.

展开

DOI:

10.1016/0014-4886(74)90122-8

被引量:

135

年份:

1974

通过文献互助平台发起求助,成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证,认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献,1~5分钟即可下载全文,部分资源由于网络原因可能需要更长时间,请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

Experimental Neurology
November 1974

引用走势

2010
被引量:11

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用