Prevalence and Functional Role of Anti-IgE Autoantibodies in Urticarial Syndromes

来自 EBSCO

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作者：

BL Gruber，ML Baeza，MJ Marchese，Vincent. Agnello，AP Kaplan

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摘要：

The prevalence of autoantibodies of immunoglobulin G (IgG) and immunoglobulin M (IgM) classes directed against myeloma immunoglobulin E (IgE) were determined in distinct subsets of urticaria, using an enzyme immunoassay. IgG anti-IgE antibodies were found in five of nine patients (55%) with cold urticaria, four of eight patients (50%) with urticarial vasculitis, and three of six patients (50%) with chronic urticaria. IgM anti-IgE antibodies were found exclusively in cold urticaria (two of nine patients, 22%). Heating of these sera increased the binding to IgE, suggesting immune complex formation. Several positive sera were capable of inducing histamine release from normal peripheral basophils and caused a wheal-flare response upon intradermal injection. Sera containing such autoantibodies from three cold urticaria patients were studied for passive transfer of cold sensitivity. One serum containing IgG anti-IgE gave a strongly positive transfer test at 5 h but not 48 h, suggesting a pathogenic role for the IgG.

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关键词：

Basophils Humans Urticaria Immunoglobulin E Immunoglobulin G Immunoglobulin M Antibodies, Anti-Idiotypic Autoantibodies Immunoenzyme Techniques Histamine Release