Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.
摘要：
In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore, a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches chromosomes to spindle microtubules, modulates the stability of these attachments and relays the microtubule-binding status to the spindle assembly checkpoint (SAC), a cell cycle surveillance pathway that delays chromosome segregation in response to unattached kinetochores. Recent studies are shaping current thinking on how each of these kinetochore-centred processes is achieved, and how their integration ensures faithful chromosome segregation, focusing on the essential roles of kinase-phosphatase signalling and the microtubule-binding KMN protein network.
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关键词：
ANAPHASE-PROMOTING COMPLEX AURORA B KINASE CHROMOSOME SEGREGATION ROLES PROTEIN PHOSPHATASE 1 MITOTIC CHECKPOINT SACCHAROMYCES-CEREVISIAE BUDDING YEAST FISSION YEAST OUTER
DOI：
10.1038/nrm3494
被引量：
年份：
2013
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