TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.
摘要：
We formulate a two-phase paradigm of autoimmunity associated with systemic lupus erythematosus, the archetypal autoimmune disease. The initial Toll-like receptor (TLR)-independent phase is mediated by dendritic cell uptake of apoptotic cell debris and associated nucleic acids, whereas the subsequent TLR-dependent phase serves an amplification function and is mediated by uptake of TLR ligands derived from self-antigens (principally nucleic acids) complexed with autoantibodies. Both phases depend on elaboration of type I interferons (IFNs), and therapeutic interruption of induction or activity of these cytokines in predisposed individuals might have a substantial mitigating effect in lupus and other autoimmune diseases.
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关键词：
Humans Lupus Erythematosus, Systemic Autoimmune Diseases Interferon Type I Interferon-alpha Interferon-beta Autoimmunity Models, Immunological Toll-Like Receptors
DOI：
10.1038/nm1590
被引量：
年份：
2007
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掌桥科研
万方医学
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