Rho and Rac take center stage.
摘要：
Many features of cell behavior are regulated by Rho family GTPases, but the most profound effects of these proteins are on the actin cytoskeleton and it was these that first drew attention to this family of signaling proteins. Focusing on Rho and Rac, we will discuss how their effectors regulate the actin cytoskeleton. We will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins. Additionally, we will discuss how there is signaling crosstalk between family members and how various bacterial pathogens have developed strategies to manipulate Rho protein activity so as to enhance their own survival.
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关键词：
Animals Humans Cell Membrane GTP Phosphohydrolases Guanine Nucleotide Exchange Factors rho GTP-Binding Proteins rac GTP-Binding Proteins Bacterial Proteins Receptors, Growth Factor Phylogeny
DOI：
10.1016/S0092-8674(04)00003-0
被引量：
年份：
2004
Elsevier
Taylor & Francis
Wiley
万方医学
掌桥科研
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