Highly Efficient Monophosphine-Based Catalyst for the Palladium-Catalyzed SuzukiMiyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters
摘要：
A highly active and efficient catalyst system derived from a palladium precatalyst and monophosphine ligands 1 or 2 for the SuzukiMiyaura cross-coupling reaction of heteroaryl boronic acids and esters has been developed. This method allows for the preparation of a wide variety of heterobiaryls in good to excellent yields and displays a high level of activity for the coupling of heteroaryl chlorides as well as hindered aryl and heteroaryl halides. Specific factors that govern the efficacy of the transformation for certain heterocyclic motifs were also investigated.
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DOI：
10.1021/ja068577p
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年份：
2007
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来源期刊
Journal of the American Chemical Society
2007/07/24
引用走势
2010
被引量：138
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