Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells
摘要：
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1cytokine, interferon-γ (IFN-γ). IFN-γ is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-γ production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-γ, is controlled by distinct transcriptional mechanisms within the T cell lineage.
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关键词：
Animals Mice, Inbred BALB C Mice, Inbred C57BL Mice CD4-Positive T-Lymphocytes Th1 Cells Leishmania major T-Lymphocytes, Cytotoxic Cell Line Leishmaniasis, Cutaneous
DOI：
10.1126/science.1065543
被引量：
年份：
2002
BMJ
万方医学
Semantic Scholar
dx.doi.org
Europe PMC
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