PARTICULATE COMPOSITIONS OF TUBULIN INHIBITOR
申请(专利)号:
WO2005US39922
申请日期:
2005-11-03
公开/公告号:
WO2006052712A1
公开/公告日期:
2006-05-18
申请(专利权)人:
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;PAPADOPOULOS, PAVLOS;RAAB, GERHARD;DOTY, MARK;KIPP, JAMES E.;ROESSLER, BERTHOLD
被引量:
摘要:
The present invention is directed to novel pharmaceutical compositions comprinsing nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as "Indibulin", and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.
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