Enantioselective organocatalytic Michael addition of malonate esters to nitro olefins using bifunctional cinchonine derivatives.
摘要：
A family of 9-amino9-deoxy epicinchonine derivatives, possessing a range of mono- and bidentate hydrogen bond donor groups at the 9-position, were synthesised and evaluated for asymmetric organocatalytic activity in the dimethyl malonate Michael addition to β-nitrostyrene; thiourea derivative1ewas identified as the most effective bifunctional organic catalyst and found to induce high enantioselectivity in the malonate ester Michael addition reaction to a range of nitro olefins.
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关键词：
diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism carboxylic acid esters (benzene compounds carboxylic acid derivatives (naphthalene compounds furan derivatives carboxylic acid esters (acyclic compounds
DOI：
10.1039/b508833j
被引量：
年份：
2005
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