Enantioselective organocatalytic Michael addition of malonate esters to nitro olefins using bifunctional cinchonine derivatives.

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83

作者:

J YeDJ DixonPS Hynes

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摘要:

A family of 9-amino9-deoxy epicinchonine derivatives, possessing a range of mono- and bidentate hydrogen bond donor groups at the 9-position, were synthesised and evaluated for asymmetric organocatalytic activity in the dimethyl malonate Michael addition to β-nitrostyrene; thiourea derivative1ewas identified as the most effective bifunctional organic catalyst and found to induce high enantioselectivity in the malonate ester Michael addition reaction to a range of nitro olefins.

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DOI:

10.1039/b508833j

被引量:

882

年份:

2005

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来源期刊

Cheminform
20050830

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2010
被引量:148

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