Expression and modulation of estrogen receptors in human breast cancer
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32
摘要：
Estrogen receptors have been traced at the tissue level in premalignant and malignant changes of human mammary gland by an immunoperoxidase technique using a monoclonal antibody against the receptor protein. Proliferative premalignant cells show an increased and homogeneous expression of the estrogen receptor by this technique; it seems that a constitutive expression of the receptor may play a role in the promotional carcinogenetic process. Moreover, infiltrating tumors show a striking heterogeneity in the cellular expression of estrogen receptor, which seems related to differentiation level.
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DOI：
10.1016/0022-4731(85)90025-1
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年份：
1985
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