Stem cell properties of human dental pulp stem cells.

来自 EBSCO

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297

作者：

S Gronthos，J Brahim，W Li，LW Fisher，N Cherman，A Boyde，P Denbesten，PG Robey，S Shi

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摘要：

In this study, we characterized the self-renewal capability, multi-lineage differentiation capacity, and clonogenic efficiency of dental pulp stem cells (DPSCs). DPSCs were capable of forming ectopic dentin and associated pulp tissue in vivo. Stromal-like cells were reestablished in culture from primary DPSC transplants and re-transplanted into immunocompromised to generate a dentin-pulp-like tissue, demonstrating their self-renewal capability. DPSCs were also found to be capable of differentiating into adipocytes and neural-like cells. The odontogenic potential of 12 individual single-colony-derived DPSC strains was determined. Two-thirds of the single-colony-derived DPSC strains generated abundant ectopic dentin in vivo, while only a limited amount of dentin was detected in the remaining one-third. These results indicate that single-colony-derived DPSC strains differ from each other with respect to their rate of . Taken together, these results demonstrate that DPSCs possess stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation.

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关键词：

stem cell odontoblasts dentin in vivo transplantation

DOI：

10.1177/154405910208100806

被引量：

3062

年份：

2003