Continuous kinetic resolution catalysed by cross-linked enzyme aggregates, 'CLEAs', in supercritical CO2
摘要：
We report the use of cross-linked enzyme aggregates (CLEAs) to catalyse the kinetic resolution of tetralol and 1-phenylethanol in a continuous supercritical carbon dioxide (scCO2) system. We describe the performance of the CLEA fromCandida antarcticalipase B (CALB) and compare this to the catalytic activity of Novozym 435 (CALB immobilised on a macroporous acrylic resin). In addition, we report a two-stage reaction with the kinetic resolution of 1-phenylethanol performed in series with the metal (Pd) catalysed hydrogenation of acetophenone. Reactions performed in series have a potential economic advantage as the second, and subsequent reactions do not require additional expenditure of energy for re-pressurization of solvent.
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关键词：
CARBON-DIOXIDE BIOCATALYTIC SYNTHESIS ORGANIC-SOLVENTS COMPRESSED GASES WATER ACTIVITY LIPASE FLUIDS CRYSTALS ENHANCEMENT ACRYLATES
DOI：
10.1039/b604738f
被引量：
年份：
2006
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