Pathogenesis of Chronic Obstructive Pulmonary Disease
摘要：
The pathogenesis of chronic obstructive pulmonary disease (COPD) encompasses a number of injurious processes, including an abnormal inflammatory response in the lungs to inhaled particles and gases. Other processes, such as failure to resolve inflammation, abnormal cell repair, apoptosis, abnormal cellular maintenance programs, extracellular matrix destruction (protease/antiprotease imbalance), and oxidative stress (oxidant/antioxidant imbalance) also have a role. The inflammatory responses to the inhalation of active and passive tobacco smoke and urban and rural air pollution are modified by genetic and epigenetic factors. The subsequent chronic inflammatory responses lead to mucus hypersecretion, airway remodeling, and alveolar destruction. This article provides an update on the cellular and molecular mechanisms of these processes in the pathogenesis of COPD.
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关键词：
Humans Pulmonary Disease, Chronic Obstructive Forced Expiratory Flow Rates Smoking Prognosis Risk Factors
DOI：
10.1016/j.ccm.2007.06.008
被引量：
年份：
2007
Elsevier
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万方医学
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