The Structure and Receptor Binding Properties of the 1918Influenza Hemagglutinin.
摘要：
The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the vims involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.
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关键词：
Animals Humans Influenza A virus Sialic Acids Hemagglutinin Glycoproteins, Influenza Virus Membrane Glycoproteins Crystallography, X-Ray Sequence Alignment Protein Conformation Protein Structure, Tertiary
DOI：
10.1126/science.1093155
被引量：
年份：
2004
Semantic Scholar
万方医学
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