Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.
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105
摘要：
Immunization of with receptor (AChR) protein from the electric organs of and induces an autoimmune response to the AChR of mammalian skeletal muscle. and develop experimental autoimmune (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The indicence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to (MG) of in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic muscle AChR in the serum of with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and mg.
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DOI：
10.1084/jem.141.6.1365
被引量：
年份：
1975
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