Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
摘要：
The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion. Intracellular reactive oxygen species and lipid peroxides rose rapidly in control cells depleted of glutathione, whereas cells expressing Bcl-2 displayed a blunted increase and complete survival. Modulation of the increase in reactive oxygen species influenced the degree of cell death. Yeast mutants null for superoxide dismutase were partially rescued by expression of Bcl-2. Thus, Bcl-2 prevents cell death by decreasing the net cellular generation of reactive oxygen species.
展开
关键词：
Neurons Cell Line Animals Saccharomyces cerevisiae Hydroxyl Radical Iron Reactive Oxygen Species Superoxide Dismutase Methionine Sulfoximine Buthionine Sulfoximine
DOI：
10.1126/science.8235659
被引量：
年份：
1993
Semantic Scholar
万方医学
doi.org
dx.doi.org
NCBI
查看更多
JSTOR
Cell Press
NCBI
Europe PMC
Oxford Univ Press
JBC
AACR
dialnet.unirioja.es
adsabs.harvard.edu
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
nejm.org
ajpregu.physiology.org
jimmunol.org
dev.biologists.org
molpharm.aspetjournals.org
jurology.com
jneurosci.org
mysciencework.com
diabetes.diabetesjournals.org
jcb.rupress.org
pubfacts.com
jn.nutrition.org
onAcademic
www.socolar.com
sciencemag.org
highbeam.com
jacionline.org
journal-of-hepatology.eu
emboj.embopress.org
ganino.com
(全网免费下载)
cghjournal.org
bloodjournal.org
SAGE
stroke.ahajournals.org
jvi.asm.org
fertstert.org
fasebj.org
go.galegroup.com
ResearchGate
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
