摘要：

1. 1. Current and older hypotheses on the mode of action of nonsteroid anti-inflammatory drugs (NSAID) are reviewed. 2. 2. It is shown that even the most convincing concept that NSAID exert their action by inhibiting the biosynthesis of prostaglandins (PG's) leaves several questions unanswered. 3. 3. They may be answered by the results of recent studies which show that acidic NSAID exert a specific pharmacokinetic behaviour leading to high concentrations of these drugs in inflamed tissue and correspondingly causes localized pharmacodynamic effects.

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