摘要：

not available for EP142341of corresponding document:Acylated hydroxamates (I) or their salts are new. Acylated hydroxamates of formula (I): R-AS-AS-NH-O-C(=E)-R' (I) or their salts are new. R = 1-9C alkyl, 2-9C alkenyl, 2-9C alkynyl (all optionally branched), an acyl-residue containing a urethane or peptide, 3-9C cycloalkyl, 4-9C carbocyclic, 5-14C aryl, 3-9C heteroaryl, 3-9C heterocyclic (all optionally substituted) or H; AS-AS = dipeptide or its mimetic; E = O or S; and R' = 1-9C alkyl, 2-9C alkenyl, 2-9C alkynyl (all optionally branched), 2-9C heterocycloalkyl, 3-9C heterocycloalkenyl, 3-9C heteroaryl, 3-9C heterocyclic (containing 6 heteroatoms in the ring), 3-9C cycloalkyl, 4-9C cycloalkenyl, 5-14C aryl, amino acid, peptide, peptide mimetic (all optionally substituted), H, alkoxy, alkenyloxy, alkynyloxy, carbocyclicoxy, heteroaryloxy, heterocyclicoxy, thioether or a substituted residue. AN Independent claim is included for the use of (I) in the preparation of a medicament for the treatment of diseases of mammals by modulation of the activity of cysteine protease dipeptidyl peptidase 1 (DP 1) and/or DP 1-like enzymes.

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