FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

来自 Semantic Scholar

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阅读量：

262

作者：

DA Brown，E London

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摘要：

Recent studies showing that detergent-resistant membrane fragments can be isolated from cells suggest that biological membranes are not always in a liquid-crystalline phase. Instead, sphingolipid and cholesterol-rich membranes such as plasma membranes appear to exist, at least partially, in the liquid-ordered phase or a phase with similar properties. Sphingolipid and cholesterol-rich domains may exist as phase-separated "rafts" in the membrane. We discuss the relationship between detergent-resistant membranes, rafts, caveolae, and low-density plasma membrane fragments. We also discuss possible functions of lipid rafts in membranes. Signal transduction through the high-affinity receptor for IgE on basophils, and possibly through related receptors on other hematopoietic cells, appears to be enhanced by association with rafts. Raft association may also aid in signaling through proteins anchored by glycosylphosphatidylinositol, particularly in hematopoietic cells and neurons. Rafts may also function in sorting and trafficking through the secretory and endocytic pathways.

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关键词：

membrane domain glycosphingolipid GPI-anchored protein signal transduction membrane trafficking

DOI：

10.1146/annurev.cellbio.14.1.111

被引量：

6258

年份：

1998