B lymphocytes express and lose syndecan at specific stages of differentiation.

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摘要：

Lymphopoietic cells require interactions with bone marrow stroma for normal maturation and show changes in to matrix during their differentiation. Syndecan, a -rich integral , functions as a matrix receptor by cells to interstitial , , and thrombospondin. Therefore, we asked whether syndecan was present on the surface of lymphopoietic cells. In bone marrow, we find syndecan only on precursor B cells. Expression changes with pre-B in the marrow and with B-to plasma cells in interstitial matrices. Syndecan on B cell precursors is more heterogeneous and slightly larger than on plasma cells. Syndecan 1) is lost immediately before maturation and release of B lymphocytes into the , 2) is absent on circulating and peripheral B lymphocytes, and 3) is reexpressed upon their differentiation into immobilized plasma cells. Thus, syndecan is expressed only when and where B lymphocytes associate with . These results indicate that B cells differentiating in vivo alter their matrix receptor expression and suggest a role for syndecan in B cell stage-specific .

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关键词：

Animals Mice, Inbred BALB C Mice B-Lymphocytes Hematopoietic Stem Cells Extracellular Matrix Proteoglycans Membrane Glycoproteins Cell Differentiation Syndecan-1