Asymmetric organocatalytic nitroaldol reaction of α-ketoesters: stereoselective construction of chiral tertiary alcohols at subzero temperature

阅读量:

42

作者:

K TakadaN TakemuraK ChoY SohtomeK Nagasawa

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摘要:

Asymmetric nitroaldol reaction of α-ketoesters was explored using a guanidine–thiourea bifunctional organocatalyst at temperatures below the freezing point of water. The new reaction protocol can be applied to the nitroaldol reaction of nitroalkanes and α-ketoesters to construct the adjacent stereocenters of the chiral tertiary alcohol product with high diastereo- and enantioselectivity.Graphical abstract

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DOI:

10.1016/j.tetlet.2008.01.030

被引量:

172

年份:

2008

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来源期刊

Cheminform
2008

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2011
被引量:53

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