Asymmetric organocatalytic nitroaldol reaction of α-ketoesters: stereoselective construction of chiral tertiary alcohols at subzero temperature
摘要：
Asymmetric nitroaldol reaction of α-ketoesters was explored using a guanidine–thiourea bifunctional organocatalyst at temperatures below the freezing point of water. The new reaction protocol can be applied to the nitroaldol reaction of nitroalkanes and α-ketoesters to construct the adjacent stereocenters of the chiral tertiary alcohol product with high diastereo- and enantioselectivity.Graphical abstract
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关键词：
hydroxycarboxylic acids (ether carboxylic acids) (acyclic compounds) and esters nitro alcohols diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) hydroxycarboxylic acids (ether carboxylic acids) and esters (benzene compounds)
DOI：
10.1016/j.tetlet.2008.01.030
被引量：
年份：
2008
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