Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras
摘要：
The pathways by which mammalian Ras proteins induce cortical actin rearrangement and cause cellular transformation are investigated using partial loss of function mutants of Ras and activated and inhibitory forms of various postulated target enzymes for Ras. Efficient transformation by Ras requires activation of other direct effectors in addition to the MAP kinase kinase kinase Raf and is inhibited by inactivation of the PI 3-kinase pathway. Actin rearrangement correlates with the ability of Ras mutants to activate PI 3-kinase. Inhibition of PI 3-kinase activity blocks Ras induction of membrane ruffling, while activated PI 3-kinase is sufficient to induce membrane ruffling, acting through Rac. The ability of activated Ras to stimulate PI 3-kinase in addition to Raf is therefore important in Ras transformation of mammalian cells and essential in Ras-induced cytoskeletal reorganization.
展开
关键词：
Aorta Endothelium, Vascular COS Cells 3T3 Cells Cell Membrane Cytoskeleton Animals Swine Mice Morpholines
DOI：
10.1016/S0092-8674(00)80226-3
被引量：
年份：
1997
Elsevier
Elsevier
(全网免费下载)
掌桥科研
万方医学
Semantic Scholar
(全网免费下载)
查看更多
dx.doi.org
Europe PMC
Cell Press
NCBI
Cell Press
(全网免费下载)
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
mendeley.com
ajpcell.physiology.org
cghjournal.org
jada.ada.org
d.scholar.cnki.net
emboj.embopress.org
readcube.com
infona.pl
discovery.ucl.ac.uk
mct.aacrjournals.org
molbiolcell.org
addgene.org
scienceopen.com
core.ac.uk
(全网免费下载)
repository.cshl.edu
ukpmc.ac.uk
yadda.icm.edu.pl
Elsevier
(全网免费下载)
Semantic Scholar
(全网免费下载)
Cell Press
(全网免费下载)
ResearchGate
(全网免费下载)
core.ac.uk
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
