A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
摘要：
A 73-kilodalton (kD) intracellular protein was found to bind to peptide regions that target intracellular proteins for lysosomal degradation in response to serum withdrawal. This protein cross-reacted with a monoclonal antibody raised to a member of the 70-kD heat shock protein (hsp70) family, and sequences of two internal peptides of the 73-kD protein confirm that it is a member of this family. In response to serum withdrawal, the intracellular concentration of the 73-kD protein increased severalfold. In the presence of adenosine 5'-triphosphate (ATP) and MgCl2, the 73-kD protein enhanced protein degradation in two different cell-free assays for lysosomal proteolysis.
展开
DOI：
10.1126/science.2799391
被引量：
年份：
1989
Taylor & Francis
Semantic Scholar
万方医学
Semantic Scholar
dx.doi.org
查看更多
NCBI
Cell Press
JSTOR
NCBI
Europe PMC
Oxford Univ Press
JBC
adsabs.harvard.edu
ProQuest
ResearchGate
EBSCO
elifesciences.org
onAcademic
circres.ahajournals.org
uniprot.org
www.socolar.com
ajpcell.physiology.org
jleukbio.org
cghjournal.org
cshperspectives.cshlp.org
jcb.rupress.org
nutrition.highwire.org
jn.nutrition.org
emboj.embopress.org
pharmrev.aspetjournals.org
scienceopen.com
jimmunol.org
molbiolcell.org
highbeam.com
pubfacts.com
sciencemag.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
