摘要：

The in vitro anti-fungal activity of diorganotin(V) carboxylate complexes, [N-(2-carboxyphenyl)salicylideneiminato] dimethyltin(IV) (1), bis(µ₃-oxo)bis(µ-O-aminobenzoato-O,O′)bis(O-aminobenzoato)tetrakis[dimethyltin(IV)] (2) and bis(O- aminobenzoato-O,O′)di-n-butyltin(IV) (3) has been screened against Candida albicans. The complexes, prepared by minor modifications of a literature method, have been fully characterized. The biological activities of complexes 1–3 on cultures of Candida albicans have been studied and the related mechanism has been investigated. No changes in DNA integrity or in the mitochondria function have been observed. However, all the tin compounds were found to reduce the ergosterol biosynthesis. The compounds have inhibitory concentrations (IC₅₀) in the range of 7.5–20.0 µg ml⁻¹, with compound 3 the most active. These results were compared with those provided by the literature, using m

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