摘要：

Objective To compare the effect of inhibiting neointimal hyperplasia between domestic sirolimus eluting stent(Firebird TM stent)and the TaxusTM stent by IVUS.Methods From May 2003 to June 2007,168 patients with 236 native lesions underwent DES implantation,of which,108 patients(147 lesions)were implanted with the FirebirdTM stents and the other 60 patients(89 lesions)were implanted with the TaxusTM stent.Quantitative angiography(QCA)and intravascular ultrasound(IVUS)analysis were performed at one-year follow-up.Results The baseline clinical and angiographic characteristics between the two groups were similar.There were less in-stent late loss(0.17±0.29 mm vs 0.43±0.51 mm,P0.0001)and in-segment late loss(0.18±0.36 mm vs 0.38±0.33 mm,P0.003)in the Firebird TM stent group than in the Taxus TM stent group.But the late loss in the 5-mm vessel segments immediately proximal and distal to the stent were comparable between the two groups.IVUS follow-up measurements showed no significant difference between the 2 group in stent CSA,lumen CSA,minimal stent CSA,stent volume and lumen volume.(all P0.05).But the Absolute and relative measwements of intimal hyperplasia including manifested as intimal hyperplasia area(0.35±0.58 mm2 vs 1.29±1.26 mm2),percentage of intimal hyperplasia area(5.45%±9.26% vs 17.38%±13.75%),percentage of maximal intimal hyperplasia area(9.41%±14.15% vs 31.56%±20.99%),intimal hyperplasia volume(2.09±5.46 mm3 vs 13.43±18.59 mm3)and percentage of intimal hyperplasia volume(1.68%±5.84% vs 8.62%±9.90%)were lower in the Firebird stent group than those in the Taxus stent group(all P0.05).Conclusion Implantation of the Firebird TM stent has shown lower restenosis rate compared with the Taxus TM stent in terms of the effect of inhibiting the neointimal hyperplasia.

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