摘要：

Reviews literature on the role of B-cell lymphoma/leukemia-2 gene (Bcl-2) in the regulation of programmed cell death (PCD). Unregulated PCD as a pathogenesis of many diseases; Discovery of bcl-2 and its involvement in t(14:18) translocations; Bcl-2 as a block to a final common pathway for PCD; Structure; Intracellular location and potential mechanisms of action.

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