摘要：

Manyfhe effectsf dietaryestriction (DR)n longevityndealthpan inodelrganismsaveeen linkedoeduced proteinndminocid (AA) intakendhetimulationfpecific nutrientignaling pathways.tudies in yeastavehownhatdditionferine,hreonine,nd valine inedia promotesellularensitizationndgingyctivating differentutonnected pathways. Proteinr essentialAestriction extendsoth lifespanndealthspan inodentodels. Inumans, proteinestriction (PR)aseenssociated witheducedancer, diabetes,ndverallortality.hus, interventionsimedt loweringhe intakef proteinsrpecificAsaneeneficialndavehe potentialoe widelydoptednd effective inptimizingealthspan.

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