Effects of the aqueous fruit extract of Solanum macrocarpum Linn on the hematological parameters of triton-induced hyperlipidemic rats

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作者：

OA Sodipo，FI Abdulrahman，UK Sandabe，JA Akinniyi

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摘要：

The dried and pulverized unripe fruit of Salanum macrocarpum (Solanaceae) was soxlet-extracted with distilled water. Studies were then undertaken on the effect of the aqueous extract on haematological parameters and the leukocytic response on triton-induced hyperlipidemic rats. Graded doses (25, 50, 100 and 200 mg/kg weight, bw) of the extract were administered intraperitoneally (i.p.) to different groups of hyperlipidemic rats for 7 days. Significant dose dependent increases (P0.05). The lymphocyte count increased with increase in extract dose, but was only significant (P0.05). The improved hematological parameters (Hb, RBC and MCV) probably imply a beneficial effect, suggesting that the plant could probably be used as an antianaemic agent. The leuckocytosis seen is probably due to the increased lymphocyte count observed. The lymphocytosis and neutrophilia in the treated rats suggest immunostimulation on the hyperlipidaemic rats.

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关键词：

Solanum macrocarpum hematological parameters hyperlipidemia differential leukocyte count triton

DOI：

10.4314/jpb.v9i1.9

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年份：

2013