N-Glucopyranosyl-5-aralkylidenerhodanines: synthesis and antibacterial and antiviral activities.

阅读量：

作者：

展开

摘要：

A series of N-(2,3,4,6-tetra- O -acetyl--D-glucopyranosyl)-5-aralkylidenerhodanines was synthesized, and the acetyl groups were removed to give N --D-glucopyranosyl-5-aralkylidenerhodanines without cleavage of the rhodanine ring by means of acid hydrolysis. Alkaline hydrolysis with ammonia in methanol resulted in cleavage to N -glu cosylthiourea, providing evidence for N -glycoside formation. A number of the rhodanine derivatives, especially those with nitro or chloro groups in the aromatic ring, showed antibacterial activity. N --D-Glucopyra nosyl-5-(4-nitrobenzylidene)rhodanine showed antiviral activity by in hibition of viral RNA synthesis. Some effect on blood sugar levels also was observed with several rhodanines.

展开

关键词：

Rhodanine derivatives, various - synthesized, evaluated for antibacterial and antiviral activities Antibacterial activity - eval uated in various rhodanine derivatives Antiviral activity - evaluated in various rhodanine derivatives Structure-activity relationships - various rhodanine derivatives evaluated for antibacterial and antiviral activities

DOI：

10.1002/jps.2600661126

被引量：

年份：

2010