Total synthesis of macrosphelides A, B, and E: first application of ring-closing metathesis for macrosphelide synthesis.
摘要：
A new synthetic route for macrosphelides A, B, and E based on ring-closing metathesis (RCM) was established. The substrates for RCM could be synthesized starting from commercially available chiral materials, methyl (S)-lactate and methyl (S)- or (R)-3-hydroxybutyrate, in good overall yields. In the investigation of the key RCM step, it was found that the steric factor around the reaction site significantly affected the reaction rate of macrocyclization. A detailed account regarding this synthetic study is described herein.
展开
关键词：
antibiotics metathesis reactions ring closure reactions multi‐membered O,S‐heterocycles (O or S ring members
DOI：
10.1002/chin.200422222
被引量：
年份：
2004
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
