摘要：

The present invention is directed to flagellin and its use as an adjuvant for vaccination. Preferably, flagellin is membrane bound, which might be achieved by using the mammalian surface display plasmid pDisplay. The invention can be used in vaccine formulations to improve immunity against any other antigen administered at the same localization. The antigen can be administered in the same construct as flagellin or in any other formulation given at the same localization. As an alternative flagellin can be used to stimulate immunity against antigens expressed at a specific location. Flagellin can also be used to induce local inflammation with the purpose of creating a model for inflammation.

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