A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP
摘要：
CD22 is a membrane immunoglobulin (mlg)-associated protein of B cells. CD22 is tyrosine-phosphorylated when mlg is ligated. Tyrosine-phosphorylated CD22 binds and activates SHP, a protein tyrosine phosphatase known to negatively regulate signaling through mlg. Ligation of CD22 to prevent its coaggregation with mlg lowers the threshold at which mlg activates the B cell by a factor of 100. In secondary lymphoid organs, CD22 may be sequestered away from mlg through interactions with counterreceptors on T cells. Thus, CD22 is a molecular switch for SHP that may bias mlg signaling to anatomic sites rich in T cells.
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关键词：
Antigen receptor Adhesion molecule Moth eaten Expression Cd40. Mice Lymphocytes Kinases Domains Cd19
DOI：
10.1126/science.7618087
被引量：
年份：
1995
万方医学
掌桥科研
Semantic Scholar
dx.doi.org
Cell Press
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