Oral antidiabetic agents: current role in type 2 diabetes mellitus.

Type 2 diabetes mellitus is a progressive and complex disorder that is difficult to treat effectively in the long term. The majority of patients are overwe...

AJ Krentz，CJ Bailey - 《Drugs》

Comprehensive analysis of kinase inhibitor selectivity.

We tested the interaction of 72 kinase inhibitors with 442 kinases covering >80% of the human catalytic protein kinome. Our data show that, as a class, typ...

MI Davis，JP Hunt，S Herrgard，... - 《Nature Biotechnology》

Oral Antidiabetic Agents: Current Role in Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus is a progressive and complex disorder that is difficult to treat effectively in the long term. The majority of patients are overwe...

Krentz，J Andrew，Bailey，... - 《Drugs》

Best Practices for QSAR Model Development, Validation, and Exploitation

After nearly five decades in the making, QSAR modeling has established itself as one of the major computational molecular modeling methodologies. As any ma...

A Tropsha - 《Molecular Informatics》

PPARγ signaling and metabolism: the good, the bad and the future.

Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor- (PPAR) and are h...

M Ahmadian，JM Suh，N Hah，... - 《Nature Medicine》

Kidney disease and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.

To describe the development and progression of neuropathy and related findings among patients with type 1 diabetes who participated in the Diabetes Control...

CL Martin，JW Albers，R Pop-Busui - 《Diabetes Care》

Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis

To assess the efficacy and safety of dipeptidyl peptidase-4 (DPP-4) inhibitors compared with metformin as monotherapy, or with other commonly used hypoglyc...

T Karagiannis，P Paschos，K Paletas，... - 《Bmj》

Effect of intensive glucose lowering on all-cause mortality, cardiovascular death, and microvascular events in type 2 diabetes

Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled ...

S Chatterjee - 《Cardiology Review》

On Two Novel Parameters for Validation of Predictive QSAR Models

Validation is a crucial aspect of quantitative structure-activity relationship (QSAR) modeling. The present paper shows that traditionally used validation ...

PP Roy，S Paul，I Mitra，... - 《Molecules》

Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis

There are several inaccuracies in this Research paper by Karagiannis and colleagues ( BMJ 2012;344:e1369, doi:10.1136/bmj.e1369). In the final paragraph of the section "Glycaemic efficacy," the risk ratio in favour of GLP-1 …

British，Medical，Journal，... - 《Bmj》