A cell-surface molecule involved in organ-specific homing of lymphocytes

作者:

WM GallatinIL WeissmanEC Butcher

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摘要:

Lymphocytes migrate from the bloodstream by recognizing and binding to specialized endothelial cells lining the high endothelial venules (HEV) in lymph nodes and Peyer's patches. We describe here a monoclonal antibody, MEL-14, specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV, and to be required for lymphocyte homing into lymph nodes in vivo.

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DOI:

10.1038/304030a0

被引量:

3450

年份:

1983

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2010
被引量:198

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