Amino-indanol catalyzed enantioselective reactions of 3-hydroxy-2-pyridones.
摘要：
A new bifunctional catalyst, chiral amino-indanol 1a, containing both Brnsted base and hydrogen bonding donor moieties, has been identified. It is easily prepared in a single step from commercially available amino-indanol. It was found to be an excellent catalyst for Diels-Alder reactions of both 3-hydroxy-2-pyridone and 3-hydroxy-2-pyrone. Various dienophiles including N-substituted maleimides were investigated. The Diels-Alder adducts were obtained in excellent yields and high enantioselectivities.
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关键词：
pyridine derivatives with bridges diastereoselective syntheses, enantioselective syntheses (incl. cis/trans-isomerism
DOI：
10.1021/ja900582a
被引量：
年份：
2009
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