Expression of Differentiated Functions in Mouse Neuroblastoma mediated by Dibutyryl-cyclic Adenosine Monophosphate
摘要：
CELLS derived from the mouse neuroblastoma (C1300) grown in culture are predominantly round and highly refractile. A small number of the cells are flatter and possess one or more extensions ("neurites") which may be as long as 3 mm. The proportion of these morphologically differentiated cells increases when the medium lacks serumor when 5-bromo-deoxyuridine is added. The cells also contain enzymes of neural functionand are capable of generating action potentials. We now show that differentiated characteris-tics of neuroblastoma cells can be induced by N,O-dibutyryl adenosine 3′ : 5′-monophosphate (dibutyryl-cyclicAMP).
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DOI：
10.1038/233413a0
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来源期刊
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2010
被引量：39
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