A Global Profile of Germline Gene Expression in C. elegans
摘要:
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi -related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
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关键词:
Animals Oocytes Spermatozoa Caenorhabditis elegans X Chromosome RNA-Induced Silencing Complex Proteins Cytoskeletal Proteins Helminth Proteins Caenorhabditis elegans Proteins
DOI:
10.1016/S1097-2765(00)00059-9
被引量:
年份:
2000






















































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