登录注册
高级搜索
包含全部检索词
包含精确检索词
包含至少一个检索词
不包含检索词
出现检索词的位置
文章任何位置
位于文章标题
作者
机构
出版物 期刊
会议
发表时间  - 
语言检索范围 不限
不限 英文 中文
文献
期刊
学者
论文查重 优惠
论文查重
开题分析
单篇购买
文献互助

Intrakinetochore localization and essential functional domains of Drosophila Spc105

来自 EBSCO

阅读量：

26

作者：

RB Schittenhelm，R Chaleckis，CF Lehner

展开

摘要：

The kinetochore is assembled during mitotic and meiotic divisions within the centromeric region of chromosomes. It is composed of more than eighty different proteins. Spc105 (also designated as Spc7, KNL-1 or Blinkin in different eukaryotes) is a comparatively large kinetochore protein, which can bind to the Mis12/MIND and Ndc80 complexes and to the spindle assembly checkpoint components Bub1 and BubR1. Our genetic characterization of Drosophila Spc105 shows that a truncated version lacking the rapidly evolving, repetitive central third still provides all essential functions. Moreover, in comparison with Cenp-C that has previously been observed to extend from the inner to the outer kinetochore region, full-length Spc105 is positioned further out and is not similarly extended along the spindle axis. Thus, our results indicate that Spc105 forms neither an extended link connecting inner Cenp-A chromatin with outer kinetochore regions nor a scaffold constraining kinetochore subcomplexes and spindle assembly checkpoint components together into a geometrically rigid supercomplex. Spc105 seems to provide a platform within the outer kinetochore allowing independent assembly of various kinetochore components.

展开

关键词：

centromere chromosome segregation kinetochore mitosis spindle assembly checkpoint

DOI：

10.1038/emboj.2009.188

被引量：

56

年份：

2014

收藏 引用 批量引用 分享
全部来源 免费下载 求助全文 全文购买

通过文献互助平台发起求助，成功后即可免费获取论文全文。

我们已与文献出版商建立了直接购买合作。

你可以通过身份认证进行实名认证，认证成功后本次下载的费用将由您所在的图书馆支付

您可以直接购买此文献，1~5分钟即可下载全文，部分资源由于网络原因可能需要更长时间，请您耐心等待哦~

身份认证 全文购买

相似文献

参考文献

引证文献

来源期刊

Embo Journal
2014/2/11 0:00:00

研究点推荐

引用走势

2016
被引量：13

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用！

引用