Cartilage engineering: a crucial combination of cells, biomaterials and biofactors
摘要：
Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. The lack of efficient modalities of treatment has prompted research into tissue engineering combining chondrogenic cells, scaffold materials and environmental factors. The aim of this review is to focus on the recent advances made in exploiting the potential of biomaterial-assisted cell therapy for cartilage engineering. We discuss the requirements for identifying additional specific growth factors and evaluating the optimal combination of cells, growth factors and scaffolds that is able to respond to the functional demand placed upon cartilage tissue replacement in clinics. Finally, some of the major obstacles encountered in cartilage engineering are discussed, as well as future trends in clinical applications.
展开
关键词：
Animals Bioartificial Organs Biocompatible Materials Biological Factors Cartilage Chondrocytes Humans Organ Culture Techniques Tissue Engineering
DOI：
10.1016/j.tibtech.2009.02.005
被引量：
年份：
2009
Elsevier
国家科技图书文献中心
(权威机构)
Semantic Scholar
万方医学
dx.doi.org
查看更多
Europe PMC
NCBI
NCBI
Cell Press
Cell Press
(全网免费下载)
AGRIS
ResearchGate
ProQuest
EBSCO
ajpcell.physiology.org
mendeley.com
学术范
scienceopen.com
deepdyve.com
infona.pl
oarsijournal.com
pubfacts.com
bvsalud.org
onAcademic
rsif.royalsocietypublishing.org
www.socolar.com
学术范
(全网免费下载)
Cell Press
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
