Medical progress: Nonalcoholic fatty liver disease
摘要:
Nonalcoholic fatty liver disease is an increasingly recognized condition that may progress to end-stage liver disease. The patho- logical picture resembles that of alcohol-induced liver injury, but it occurs in patients who do not abuse al- cohol. 1,2 A variety of terms have been used to describe this entity, including fatty-liver hepatitis, nonalcoholic Lannec's disease, diabetes hepatitis, alcohol-like liv- er disease, and nonalcoholic steatohepatitis. Nonal- coholic fatty liver disease is becoming the preferred term, and it refers to a wide spectrum of liver dam- age, ranging from simple steatosis to steatohepatitis, advanced fibrosis, and cirrhosis. Steatohepatitis (non- alcoholic steatohepatitis) represents only a stage with- in the spectrum of nonalcoholic fatty liver disease. The clinical implications of nonalcoholic fatty liver disease are derived mostly from its common occur- rence in the general population and its potential to progress to cirrhosis and liver failure. Nonalcoholic fatty liver disease should be differentiated from ste- atosis, with or without hepatitis, resulting from sec- ondary causes (Table 1), because these conditions have distinctly different pathogeneses and outcomes.
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2002
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