Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system
摘要：
The medicinal properties of exogenous cannabinoids have been recognized for centuries and can largely be attributed to the activation in the nervous system of a single G-protein-coupled receptor, CB1. However, the beneficial properties of cannabinoids, which include relief of pain and spasticity, are counterbalanced by adverse effects such as cognitive and motor dysfunction. The recent discoveries of anandamide, a natural lipid ligand for CB1, and an enzyme, fatty acid amide hydrolase (FAAH), that terminates anandamide signaling have inspired pharmacological strategies to augment endogenous cannabinoid ('endocannabinoid') activity with FAAH inhibitors, which might exhibit superior selectivity in their elicited behavioral effects compared with direct CB1 agonists.
展开
关键词：
2-AG 2-arachidonoyl glycerol 2-arachidonoyl glycerol CB cannabinoid cannabinoid FAA fatty acid amide fatty acid amide FAAH fatty acid amide hydrolase fatty acid amide hydrolase GPCR G-protein-coupled receptor G-protein-coupled receptor
DOI：
10.1016/S1367-5931(03)00079-6
被引量：
年份：
2003
Elsevier
Elsevier
(全网免费下载)
国家科技图书文献中心
(权威机构)
ACS
Semantic Scholar
(全网免费下载)
查看更多
掌桥科研
万方医学
dx.doi.org
Ingenta
NCBI
Europe PMC
Oxford Univ Press
NCBI
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
ajpheart.physiology.org
mysciencework.com
mendeley.com
scripps.edu
(全网免费下载)
scienceopen.com
www.socolar.com
deepdyve.com
pherobase.com
学术范
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
