Asymmetry Bioreduction of Ethyl Acetoacetate Catalyzed by Baker's Yeast
摘要:
Optically active ethyl ( S ) 3 hydroxybutyrate (E 3 HB), a useful chiral synthon, was prepared by stereoselective bioreduction of ethyl acetoacetate with pressed baker's yeast ( Saccharamyces cerevisiae). Effects of energy source, sucrose concentration, reaction temperature, substrate concentration and amount of pressed yeast on the yield and enantiometric excess ( ee ) of the product were examined respectively. The results showed that 200g/L of sucrose as energy source, 35℃, 170g/L of pressed yeast and 0.2mol/L of substrate were optimal for the asymmetric bioreduction of ethyl acetoacetate.
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关键词:
biocatalysis asymmetric reduction baker's yeast ethyl acetoacetate ethyl ( S ) 3 hydryoxybutyrate
被引量:
年份:
2000
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