Removal of Thioacetal Protecting Groups by Cerium (IV) Ammonium Nitrate - Hydrolysis of 1,3-Dithiannes
摘要：
In the course of our work on umpolung of ±,-ethylenic ketones and aldehydes1, the use of thioacetalised -ketophosphonium salts and ylids led us to investigate the hydrolysis of 1,3-dithianes. Among the known methods of removal of thioacetal protecting groups2, the one using cerium (IV) ammonium nitrate (CAN) has the advantages of a fast reaction with easy work-up and good to very good yields3. This method has been widely applied for preparative purposes using four equivalents of the cerium salt. However it does not seem that a theoretical explanation has been brought for the use of such a quantity of CAN. The only one proposed4 deals with a mechanism similar to the one involving mercury (II) salts, where indeed, four equivalents of metallic salt are not necessary5.
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关键词：
Homogeneous immunoassay immunoassay, homogeneous enzyme immunoassay immunoassay, enzyme antigens antibodies ligand binding separation-free enzyme immunoassay substrate and prosthetic group labels
DOI：
10.1080/00397918108061872
被引量：
年份：
1981
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