Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

来自万方医学

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183

作者：

D Langleben

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摘要：

BACKGROUND: is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells in the walls of small pulmonary arteries. is a potent endothelium-derived vasoconstrictor with important mitogenic properties. It has therefore been suggested that may contribute to increases in pulmonary arterial tone or smooth-muscle proliferation in patients with . We studied the sites and magnitude of production in the lungs of patients with various causes of .: We studied the distribution of -like immunoreactivity (by immunocytochemical analysis) and (by in situ hybridization) in lung specimens from 15 control subjects, 11 patients with plexogenic pulmonary (grades 4 through 6), and 17 patients with and pulmonary of grades 1 through 3.: In the controls, -like immunoreactivity was rarely seen in vascular endothelial cells. In the patients with , -like immunoreactivity was abundant, predominantly in endothelial cells of pulmonary arteries with medial thickening and intimal fibrosis. Likewise, was increased in the patients with and was expressed primarily at sites of -like immunoreactivity. There was a strong correlation between the intensity of -like immunoreactivity and pulmonary vascular resistance in the patients with plexogenic pulmonary , but not in those with . CONCLUSIONS: is associated with the increased expression of in vascular endothelial cells, suggesting that the local production of may contribute to the vascular abnormalities associated with this disorder.

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关键词：

Humans Lung Hypertension, Pulmonary Endothelin-1 Radioimmunoassay Prospective Studies Adult Aged Middle Aged Chromatography, High Pressure Liquid