A novel binuclear palladium complex with benzothiazole-2-thiolate: synthesis, crystal structure and interaction with DNA.

来自 dx.doi.org

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阅读量：

134

作者：

EJ Gao，KH Wang，XF Gu，Y Ying，YG Sun，WZ Zhang，HX Yin，Q Wu，MC Zhu，XM Yan

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摘要：

The novel Pd(II) complex, [Pd 2(μ-bzta) 4] · 1.5DMSO (where bzta = benzothiazole-2-thiolate) has been synthesized and structurally characterized by element analysis, IR and single-crystal X-ray diffractometry. In the binuclear complex, two palladium(II) are bridged by four deprotonated benzothiazole-2-thialate in a head to tail disposition and the distance of the two Pd(II) is 2.747 . Three-dimensional structure of the complex was constructed though SS (3.339 ) weak interaction and ππ stack. The binding of the title complex with fish sperm DNA (FS-DNA) has been investigated by absorption and fluorescence spectra. The results indicate that the complex bind to FS-DNA in an intercalative mode and the intrinsic binding constant K of the title complex with FS-DNA is about 1.2 × 10 4 M 1. Gel electrophoresis assay demonstrates the ability of the complex to cleave the pUC19 plasmid DNA.

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关键词：

Palladium (II) complex Crystal structure DNA binding

DOI：

10.1016/j.jinorgbio.2007.06.007

被引量：

114

年份：

2007