Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells
摘要：
Although T cells bearing γδ T-cell receptors have long been known to be present in the epithelial lining of many organs, their specificity and function remain elusive. In the present study, we examined the intestinal epithelia of T-cell-receptor mutant mice, which were deficient in either γδ T cells or αβ T cells, and of normal littermates. The absence of γδ T cells was associated with a reduction in epithelial cell turnover and a downregulation of the expression of major histocompatibility complex class II molecules. No such effects were observed in αβ T-cell-deficient mice. These findings indicate that intraepithelial γδ T cells regulate the generation and differentiation of intestinal epithelial cells.
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关键词：
Intestinal Mucosa Intestine Small Receptors Antigen T-Cell gamma-delta 肠粘膜 小肠 受体 抗原 T细胞 γ-δ T淋巴细胞
DOI：
10.1073/pnas.92.13.6147
被引量：
年份：
1995
BMJ
国家科技图书文献中心
(权威机构)
掌桥科研
万方医学
dx.doi.org
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