One-Pot Synthesis of Conjugated (E)-Enynones via Two Types of Cross-Coupling Reaction
摘要：
(Trimethylsilyl)ethynyl bromide can be easily transformed into conjugated (E)-enynones, whose skeleton consists of consecutive carbonyl, ethynyl, and (E)-ethenyl units, via a one-pot multicomponent Suzuki-type reaction-Sonogashira reaction sequence. Thus, a three-component coupling of (trimethylsilyl)ethynyl bromide, (E)-alk-1-enyldisiamylborane and acid chloride is achieved in a two-step, one-pot procedure, in which (E)-alk-1-enyl group is installed as nucleophile in the sp-carbon atom attached to bromine atom and acyl group is installed as electrophile in the other sp-carbon atom.
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DOI：
10.1055/s-0030-1258563
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年份：
2010
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来源期刊
Cheminform
20101001
引用走势
2011
被引量：1
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