Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
摘要：
The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains. Phosphotyrosine peptide stimulation of the phosphatase activity, resulting from peptide binding to the N-terminal SH2 domain, is linked to conformational changes within the protein, including an unprecedented allosteric transition of the N-terminal SH2 domain.
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DOI：
10.1016/S0969-2126(98)00027-6
被引量：
年份：
1998
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