Journalof Cell Biology

阅读量:

23

作者:

P Ouyang

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摘要:

Localization of signaling complexes to specific microdomains coordinates signal transduction at the plasma membrane. Using immunogold electron microscopy of plasma membrane sheets coupled with spatial point pattern analysis, we have visualized morphologically featureless microdomains, including lipid rafts, in situ and at high resolution. We find that an inner-plasma membrane lipid raft marker displays cholesterol-dependent clustering in microdomains with a mean diameter of 44 nm that occupy 35 % of the cell surface. Cross-linking an outer-leaflet raft protein results in the redistribution of inner leaflet rafts, but they retain their modular structure. Analysis of Ras

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DOI:

10.1016/S0924-2244(04)00115-3

被引量:

40

年份:

2013

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来源期刊

z cell

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2013
被引量:29

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