Wound tissue oxygen tension predicts the risk of wound infection in surgical patients.

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作者：

HW Hopf，TK Hunt，JM West，P Blomquist，JD Whitney

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摘要：

Objective:To test the hypothesis that subcutaneous wound oxygen tension (PsqO2) has a predictive relation to the development of wound infection in surgical patients.Design:A noninterventional, prospective study.Setting:A university department of surgery.Patients:One hundred thirty operative general surgical patients at notable risk of infection as predicted by an anticipated Study on the Effect of Nosocomial Infection Control (SENIC) score of 1 or greater.Outcome Measures:PsqO2was measured perioperatively. Its relation to the subsequent incidence of surgical wound infection was then determined and compared with the SENIC score as a criterion standard.Results:Although the SENIC score and PsqO2are inversely correlated, PsqO2 is the stronger predictor of infection. Low PsqO2identified patients at risk and concentrated them in a cohort that was about half the size of that identified by the SENIC score.Conclusions:Subcutaneous perfusion and oxygenation are important components of immunity to wound infections. The SENIC score identifies systemic physiological variables that are important to the development of wound infection. Nevertheless, PsqO2More-he more powerful predictor of wound infection. Moreover, PPsqOcan be manipulated by available clinical means, and thus may direct interventions to prevent infection.Arch Surg. 1997;132:997-1004

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关键词：

Humans Surgical Wound Infection Arm Injuries Postoperative Period Prospective Studies Oxygen Consumption Adult Aged Aged, 80 and over Middle Aged